منابع مشابه
MUC1-C drives DNA methylation in cancer
publications have reported a previously unrecognized role for the MUC1-C oncoprotein in regulating DNA methyltransferase (DNMT) expression and thereby DNA methylation in human cancer cells [1, 2]. The MUC1-C transmembrane protein is aberrantly overexpressed in diverse human cancers and in certain hematologic malignancies, including acute myelo-genous leukemia (AML) [3]. Dysregulation of DNMTs a...
متن کاملMUC1 expression is regulated by DNA methylation and histone H3 lysine 9 modification in cancer cells.
MUC1 is a transmembrane mucin that is highly expressed in various cancers and correlates with malignant potential. Important cancer-related genes such as p16 and E-cadherin are controlled epigenetically; however, MUC1 has been overlooked in epigenetics. Herein, we provide the first report that MUC1 gene expression is regulated by DNA methylation and histone H3 lysine 9 (H3-K9) modification of t...
متن کاملThe Impression of Histone Modification and DNA Methylation in Gastric Cancer Development: Molecular Mechanism Approach
The epigenetic alterations like histone modifications , DNA methylation and others remarkable categories including nucleosome remodeling and RNA mediated targeting have been strongly investigated recently .In this way , beside the notable importance of DNA methylation ,the histone modifications are the most important issues in the tumorogenesis and cancer progression. Moreover...
متن کاملDNA methylation and cancer.
DNA methylation is an important regulator of gene transcription, and its role in carcinogenesis has been a topic of considerable interest in the last few years. Alterations in DNA methylation are common in a variety of tumors as well as in development. Of all epigenetic modifications, hypermethylation, which represses transcription of the promoter regions of tumor suppressor genes leading to ge...
متن کاملDNA methylation in breast cancer.
Like all cancers, breast cancer is considered to result in part from the accumulation of multiple genetic alterations leading to oncogene overexpression and tumor suppressor loss. More recently, the role of epigenetic change as a distinct and crucial mechanism to silence a variety of methylated tissue-specific and imprinted genes has emerged in many cancer types. This review will briefly discus...
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ژورنال
عنوان ژورنال: Aging
سال: 2016
ISSN: 1945-4589
DOI: 10.18632/aging.101153